Robert A Casero Selected Research

Wounds and Injuries (Trauma)

3/2024	Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment.
1/2014	Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.
9/2012	Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.
9/2010	Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity.
3/2010	Polyamine catabolism is enhanced after traumatic brain injury.

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Robert A Casero Research Topics

Disease

67	Neoplasms (Cancer) 05/2024 - 03/2002
17	Carcinogenesis 01/2020 - 02/2004
14	Breast Neoplasms (Breast Cancer) 11/2021 - 07/2003
11	Inflammation (Inflammations) 01/2020 - 08/2004
10	Colonic Neoplasms (Colon Cancer) 05/2022 - 11/2003
7	Snyder Robinson syndrome 03/2024 - 12/2018
7	Carcinoma (Carcinomatosis) 01/2018 - 11/2003
6	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 02/2006
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2012 - 03/2002
5	Wounds and Injuries (Trauma) 03/2024 - 03/2010
5	Lung Neoplasms (Lung Cancer) 01/2017 - 08/2002
4	Stomach Neoplasms (Stomach Cancer) 01/2020 - 01/2005
4	Colitis 01/2018 - 08/2004
4	Infections 01/2018 - 08/2004
4	Gastritis 10/2016 - 11/2010
3	Intellectual Disability (Idiocy) 05/2024 - 12/2018
3	Tuberous Sclerosis (Bourneville's Disease) 09/2022 - 01/2018
3	Gliosis 11/2020 - 01/2018
3	Reperfusion Injury 01/2014 - 05/2003
2	Tauopathies 05/2024 - 03/2023
2	Squamous Cell Carcinoma of Head and Neck 07/2023 - 01/2022
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 01/2022
2	Adenocarcinoma of Lung 01/2022 - 01/2011
2	Triple Negative Breast Neoplasms 11/2021 - 01/2020
2	Neurodevelopmental Disorders 11/2020 - 01/2018
2	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 05/2008
2	Adenoma (Adenomas) 01/2018 - 02/2004
2	Polyps 01/2018 - 02/2004
2	Leukemia 01/2018 - 10/2005
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2018 - 02/2004
2	Acute Kidney Injury (Acute Renal Failure) 01/2017 - 05/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2014 - 03/2012
2	Ischemia 01/2014 - 05/2003
1	Fibrosis (Cirrhosis) 03/2024
1	Failure to Thrive 03/2024
1	Head and Neck Neoplasms (Head and Neck Cancer) 07/2023
1	Alzheimer Disease (Alzheimer's Disease) 03/2023

Drug/Important Bio-Agent (IBA)

89	PolyaminesIBA 05/2024 - 03/2002
28	EnzymesIBA 03/2024 - 11/2003
20	SpermidineIBA 05/2024 - 07/2003
20	SpermineIBA 03/2024 - 07/2003
13	Polyamine OxidaseIBA 01/2020 - 11/2003
12	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 11/2021 - 12/2003
11	N(1),N(11)-diethylnorspermineIBA 05/2022 - 03/2002
9	Spermine SynthaseIBA 05/2024 - 12/2018
9	Histones (Histone)IBA 10/2022 - 10/2005
8	Proteins (Proteins, Gene)FDA Link 03/2024 - 05/2003
7	Eflornithine (Ornidyl)FDA Link 11/2023 - 08/2004
6	Lysine (L-Lysine)FDA Link 03/2014 - 07/2010
6	ChromatinIBA 09/2012 - 05/2007
5	Cisplatin (Platino)FDA LinkGeneric 03/2024 - 05/2003
5	Antineoplastic Agents (Antineoplastics)IBA 10/2018 - 03/2002
5	Messenger RNA (mRNA)IBA 01/2007 - 05/2003
4	Biomarkers (Surrogate Marker)IBA 05/2024 - 05/2003
4	Small Interfering RNA (siRNA)IBA 05/2022 - 12/2005
4	PutrescineIBA 01/2022 - 07/2004
4	Oxidoreductases (Dehydrogenase)IBA 05/2019 - 07/2005
4	Histone Deacetylase InhibitorsIBA 06/2014 - 10/2005
4	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 12/2004
3	RNA (Ribonucleic Acid)IBA 03/2024 - 11/2003
3	trans-sodium crocetinate (crocetin)IBA 09/2022 - 01/2018
3	ProdrugsIBA 05/2022 - 01/2018
3	(N(1),N(12))bis(ethyl)- 6,7- dehydrospermineIBA 01/2021 - 01/2017
3	Fluorouracil (Carac)FDA LinkGeneric 01/2021 - 01/2007
3	Azacitidine (5 Azacytidine)FDA Link 01/2019 - 01/2011
3	CurcuminIBA 01/2018 - 12/2017
3	ArginaseIBA 10/2016 - 08/2004
3	CytokinesIBA 09/2012 - 12/2006
3	diamine N-acetyltransferase (spermidine acetyltransferase)IBA 01/2007 - 08/2004
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2006 - 08/2004
2	tau Proteins (tau Protein)IBA 05/2024 - 03/2023
2	Polo-Like Kinase 1IBA 05/2022 - 05/2022
2	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 06/2017
2	Mechanistic Target of Rapamycin Complex 1IBA 11/2018 - 01/2018
2	Dextran SulfateIBA 01/2018 - 01/2012
2	Interleukin-17 (Interleukin 17)IBA 01/2018 - 01/2016
2	CarcinogensIBA 01/2018 - 12/2017
2	Oncogene Proteins (Oncogene Protein)IBA 06/2017 - 11/2011
2	Histone DemethylasesIBA 01/2016 - 01/2012
2	Urea (Carbamide)FDA LinkGeneric 04/2015 - 09/2012
2	ThioureaIBA 04/2015 - 09/2012
2	MethyltransferasesIBA 01/2013 - 12/2009
2	Estrogen Receptor alphaIBA 11/2012 - 07/2006
2	BiguanidesIBA 09/2012 - 07/2010
2	GuanidinesIBA 09/2012 - 07/2010
2	AcetyltransferasesIBA 09/2012 - 02/2006
2	entinostat (MS 275)IBA 01/2011 - 10/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2008 - 12/2006
2	Sulindac (Copal)FDA LinkGeneric 02/2006 - 02/2004
1	Lipocalin-2IBA 03/2024
1	VimentinIBA 03/2024
1	Fibronectins (Fibronectin)IBA 03/2024
1	CollagenIBA 03/2024
1	PlatinumIBA 07/2023
1	Amino Acids FDA Link 07/2023
1	deoxyhypusine synthaseIBA 01/2023

Therapy/Procedure

23	Therapeutics 10/2022 - 12/2003
7	Drug Therapy (Chemotherapy) 10/2022 - 01/2012
6	Chemoprevention 01/2018 - 02/2004
3	Immunotherapy 05/2024 - 01/2022